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orthotopic breast cancer mouse model  (TargetMol)


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    TargetMol orthotopic breast cancer mouse model
    Orthotopic Breast Cancer Mouse Model, supplied by TargetMol, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/orthotopic+breast+cancer+mouse+model/Anti-Breast+Cancer+Compound+Library/pmc10028116-63-32-41
    Average 90 stars, based on 1 article reviews
    orthotopic breast cancer mouse model - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Injection:

    Article Title: Regulation of DNA‐PK activity promotes the progression of TNBC via enhancing the immunosuppressive function of myeloid‐derived suppressor cells
    Article Snippet: .. 1 × 10 6 4 T1 cells resuspended with PBS were injected into the mammary fat pads of BALB/c female mice in groups A, B, C, and D per mouse, to construct orthotopic breast cancer mouse model. NU7441 was purchased from TOPSCIENCE (Shanghai, China). ..

    Construct:

    Article Title: Regulation of DNA‐PK activity promotes the progression of TNBC via enhancing the immunosuppressive function of myeloid‐derived suppressor cells
    Article Snippet: .. 1 × 10 6 4 T1 cells resuspended with PBS were injected into the mammary fat pads of BALB/c female mice in groups A, B, C, and D per mouse, to construct orthotopic breast cancer mouse model. NU7441 was purchased from TOPSCIENCE (Shanghai, China). ..



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    Image Search Results


    Development and preclinical testing of the ratiometric camera system. (a) Photo and schematic of the components of the camera. (b) Representative images acquired with the camera system showing RATIO channel of vials containing 6QC-RATIO [100 nM] which has been incubated for 30 min with either vehicle, cathepsin L [20 nM], or cathepsin L [20 nM] preincubated 30 min with cathepsin inhibitor E64d [10 μM]. (c) schematic of experimental setup for ratiometric imaging. (d) Representative RATIO camera images showing a mouse carrying two breast tumors injected with Death-Cat-RATIO [10 nmol] 24 h prior to imaging. From left to right, the panels show the brightfield image, the overlay between the Cy5 channel and the brightfield image, and the overlay between the RATIO channel and the brightfield image. The tumor closer to the camera (area 1) is located in the third mammary fat pad; the tumor further from the camera (area 2) is located in the eighth mammary fat pad. Scale bars: 1 cm. (e) Representative RATIO camera images of a mouse model of small 4T1 lesions. Representative white light photo of a splayed mouse (left) and overlay of the RGB signal and RATIO signal acquired with the ratiometric camera (right). (f) Photo of the da Vinci setup for ratiometric robotic surgery with view of the subject stage. (g) Representative images of ratiometric robotic surgery carried out in mice injected with Death-Cat-RATIO [10 nmol] 24 h prior to imaging. Images were acquired with the custom camera system and show, from left to right, the RGB channel, the Cy5 channel, the RATIO channel, and an overlay between the RGB and RATIO channel. Scale bars: 1 cm.

    Journal: ACS Central Science

    Article Title: Protease Activated Probes for Real-Time Ratiometric Imaging of Solid Tumors

    doi: 10.1021/acscentsci.3c00261

    Figure Lengend Snippet: Development and preclinical testing of the ratiometric camera system. (a) Photo and schematic of the components of the camera. (b) Representative images acquired with the camera system showing RATIO channel of vials containing 6QC-RATIO [100 nM] which has been incubated for 30 min with either vehicle, cathepsin L [20 nM], or cathepsin L [20 nM] preincubated 30 min with cathepsin inhibitor E64d [10 μM]. (c) schematic of experimental setup for ratiometric imaging. (d) Representative RATIO camera images showing a mouse carrying two breast tumors injected with Death-Cat-RATIO [10 nmol] 24 h prior to imaging. From left to right, the panels show the brightfield image, the overlay between the Cy5 channel and the brightfield image, and the overlay between the RATIO channel and the brightfield image. The tumor closer to the camera (area 1) is located in the third mammary fat pad; the tumor further from the camera (area 2) is located in the eighth mammary fat pad. Scale bars: 1 cm. (e) Representative RATIO camera images of a mouse model of small 4T1 lesions. Representative white light photo of a splayed mouse (left) and overlay of the RGB signal and RATIO signal acquired with the ratiometric camera (right). (f) Photo of the da Vinci setup for ratiometric robotic surgery with view of the subject stage. (g) Representative images of ratiometric robotic surgery carried out in mice injected with Death-Cat-RATIO [10 nmol] 24 h prior to imaging. Images were acquired with the custom camera system and show, from left to right, the RGB channel, the Cy5 channel, the RATIO channel, and an overlay between the RGB and RATIO channel. Scale bars: 1 cm.

    Article Snippet: To evaluate the performance of ratiometric optical contrast agents in vivo , we employed the 4T1 orthotopic breast cancer mouse model. We injected 4T1 (ATCC CRL-2539) mammary carcinoma cells subcutaneously into the third and eighth mammary fat pads.

    Techniques: Incubation, Imaging, Injection